Human Brain Architecture

It has been almost 20 years since Francis Crick and Ted Jones lamented the Backwardness of Human Neuroanatomy, pointing out our fundamental knowledge gap and lack of tools to provide adequate understanding of the brain circuitry that underlies complex human behavior.  While advances have been made, primarily using imaging methods, the available information about the architecture of the human brain remains sparse.

The Brain Architecture Project portal includes several components related to the human brain, as featured below:

 

The Online Brain Atlas Reconciliation Tool (OBART) aims to provide a quantitative solution to the so-called neuroanatomical nomenclature problem by comparing overlap relations between regions defined as spatial entities in different brain atlases.

 

 

The Human Brain Connectivity Database includes details (based on manual literature curation) of tract tracing or related connectivity studies conducted in human brain tissue.

 

 

Co-expression networks of genes related to addiction: this project, in collaboration with the Allen Institute for Brain Science, and funded by NIDA, examines the localization of genes previously implicated in addiction in the mouse brain (to be followed by analysis in the human brain), particularly focusing on co-expression networks consisting of multiple genes.