The goal of the Mouse Brain Architecture Project is to understand brain-wide connectivity in the mouse brain at the mesoscopic scale (Mitra 2014).

The primary data presented on this portal for wild-type connectivity consists of a comprehensive set of anterograde and retrograde tracer injections placed on a systematic grid spanning the whole mouse brain. The data was generated using a high throughput neuro-histological pipeline for doing injection-based tractography and is being processed using an integrated data analysis and web-posting pipeline for petabyte-scale histological image data.

The project was initiated with workshops in 2007-08, leading to a position paper (Bohland et al. 2009) proposing brain-wide mesoscale connectivity mapping in vertebrate brains. This original proposal also inspired corresponding efforts elsewhere including the Allen Institute mouse wildtype connectivity mapping project.